General Research
Model: mouse
Protective Effect of Molecular Hydrogen Following Different Routes of Administration on D-Galactose-Induced Aging Mice
Simplified Version Available
Unlocking the Anti-Aging Power of Hydrogen: What You Need to Know
A 2021 study found that molecular hydrogen may have anti-aging effects by reducing oxidative stress and inflammation in mice. This simple element could be the key to healthier, longer lives. As research continues, hydrogen might become a valuable tool in the fight against aging.
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Publish Year 2021 Country China Rank Positive Journal Journal of Inflammation Research Primary Topic Whole Body Secondary TopicAging Model Mouse Tertiary TopicOxidative Stress Vehicle Gas pH N/A Application Inhalation Comparison Complement
Background
Methods: The mice were administrated of H2 via different routes (4% H2 inhalation, H2-rich water drinking, and H2-rich saline injection), the aging-related biomarkers in plasma and the oxidative stress in different tissues were measured.
Methods
Results: The results showed that H2 improved aging-related biomarkers, ie, total antioxidant capacity, advanced glycation end products, tumor necrosis factor-α, free fatty acids, and alanine aminotransferase in plasma. Furthermore, H2 alleviated oxidative stress in the liver, brain, and heart by reducing the levels of lipid peroxidation and malondialdehyde and increasing the activity of superoxide dismutase. In addition, it seems that 4% H2 inhalation was the most effective regarding the amount of H2 taken up and in reducing the markers of oxidative stress in some of the tissues; however, the other routes of administration resulted in the same efficacy in most indicators.
Results
Conclusion: H2 can prevent oxidative stress in D-galactose-induced aging mice when administered by different routes.