General Research
Model: human
The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial
Simplified Version Available
Breathing Easy: How Hydrogen-Oxygen Mixtures May Help Lower Blood Pressure
A new study published in Frontiers in Pharmacology found that inhaling a low dose of hydrogen-oxygen mixture can help lower blood pressure in midlife and older adults with hypertension. The therapy has antioxidant properties and may be a complementary approach to traditional treatments. More research is needed, but the results are promising and could improve the quality of life for millions of people worldwide.
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Publish Year 2022 Country China Rank Positive Journal Frontiers in Pharmacology Primary Topic Heart Secondary TopicAging Model Human Tertiary TopicHypertension Vehicle Gas pH N/A Application Inhalation Comparison Complement Oxygen
Methods
Results: A total of 56 patients completed the study (27 in the Air group and 29 in the H2-O2 group). The right and left arm systolic blood pressure (SBP) were significantly decreased in H2-O2 group compared with the baseline levels (151.9 ± 12.7 mmHg to 147.1 ± 12.0 mmHg, and 150.7 ± 13.3 mmHg to 145.7 ± 13.0 mmHg, respectively; all p < 0.05). Meanwhile, the H2-O2 intervention significantly decreased diastolic nighttime ambulatory blood pressure by 2.7 ± 6.5 mmHg (p 0.05). When stratified by age (aged 50-59 years versus aged 60-70 years), participants in the older H2-O2 group showed a larger reduction in right arm SBP compared with that in the younger group (p < 0.05). In addition, the angiotensin II, aldosterone, and cortisol levels as well as the aldosterone-to-renin ratio in plasma were significantly lower in H2-O2 group compared with baseline (p < 0.05). No significant differences were observed in the Air group before and after the intervention.
Results
Conclusion: Inhalation of a low-dose H2-O2 mixture exerts a favorable effect on blood pressure, and reduces the plasma levels of hormones associated with hypertension on renin-angiotensin-aldosterone system and stress in midlife/older adults with hypertension.