Hydrogen Water
General Research Model: human

Real-World Effectiveness and Safety of Hydrogen Inhalation in Chinese Patients with Type 2 Diabetes: A Single-Arm, Retrospective Study

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Breathing Easy: How Hydrogen Inhalation Helps People with Type 2 Diabetes

A recent study found that hydrogen inhalation is a safe and effective therapy for managing type 2 diabetes in Chinese patients. The therapy was shown to improve glucose metabolism and reduce inflammation. While more research is needed, the findings offer hope for those living with type 2 diabetes and highlight the importance of exploring alternative therapies.

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Abstract

Publish Year 2023 Country China Rank Positive Journal Diabetes, Metabolic Syndrome, and Obesity: Targets and Therapy Primary Topic Whole Body Secondary TopicDiabetes (Type II) Model Human Tertiary TopicGlucose Metabolism Vehicle Gas pH N/A Application Inhalation Comparison Complement

Methods

Results: Of the 431 patients comprised, it is observed a significant decrease in HbA1c level (9.04±0.82% at baseline to 8.30±0.99% and 8.00±0.80% at the end, p<0.001), FPG (165.6±40.2 mg/dL at baseline to 157.1±36.3mg/dL and 143.6±32.3mg/dL at the end, p<0.001), weight (74.7±7.1kg at baseline to 74.8±10.0kg and 73.6±8.1kg at the end, p<0.001), insulin dose (49.3±10.8U/d at baseline to 46.7±8.0U/d and 45.2±8.7U/d, p<0.001). The individuals in subgroup with higher baseline HbA1c and longer daily HI time duration gain greater HbA1c decrease after 6 months. Linear regression shows that higher baseline HbA1c level and shorter diabetes duration are significantly in relation to greater HbA1c reduction. Logistics regression reveals that lower weight is associated with a higher possibility of reaching HbA1c<7%. The most common adverse event is hypoglycemia.

Results

Conclusion: HI therapy significantly improves glycemic control, weight, insulin dose, lipid metabolism, β-cell function and insulin resistance of patients with type 2 diabetes after 6 months. Higher baseline HbA1c level and shorter diabetes duration is related to greater clinical response to HI.