General Research
Model: rat
Hydrogen-rich saline prevents bone loss in diabetic rats induced by streptozotocin
Simplified Version Available
How Hydrogen-Rich Saline May Help Prevent Bone Loss in Diabetes
A 2017 study found that hydrogen-rich saline may help prevent bone loss in diabetic rats. The research suggests that this solution could have a protective effect on bones in diabetic conditions, offering hope for a potential new treatment option. This discovery may lead to new ways to use hydrogen-rich saline to improve the lives of people with diabetes.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal International Orthopaedics Primary Topic Bone Secondary TopicDiabetes (Type II) Model Rat Tertiary TopicBone Loss Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: After 12 weeks, the glucose level was significantly decreased in the DM + HRS group compared with that of the DM group. Micro-CT scans showed that bone volume/total volume, connectivity density, trabecular thickness, and trabecular number were significantly increased compared with the DM group. Mechanical results of energy, stiffness and elastic modulus in the DM + HRS group were significantly higher than in the other groups for the tibia and femur. Conclusions: The results indicate that the systemic delivery of hydrogen saline water, which is safe and well tolerated, preserves bone volume and decreases fracture risks in streptozotocin-induced diabetic status rats, whose bone structure or inherent material properties of bone tissues are changed.
Purpose
Methods: The animals were divided into three groups of 12 animals and lavaged with normal saline (normal control and DM), or hydrogen saline water (DM + HRS). General status, blood glucose level, tibial and femoral mechanical strength, and micro-CT scans of the proximal tibia were recorded and analyzed.