General Research
Model: rat
Effect of hydrogen-rich saline on cardiomyocyte autophagy during myocardial ischemia-reperfusion in aged rats
Simplified Version Available
How Hydrogen-Rich Saline Can Help Protect Your Heart
A study found that hydrogen-rich saline can help protect heart cells from damage caused by lack of blood flow. The researchers used aged rats and found that the saline increased autophagy, a natural recycling system that helps keep cells healthy. This could have big implications for human heart health and potentially lead to new treatments for heart disease.
Read Simplified ArticleAbstract
Publish Year 2015 Country China Rank Positive Journal National Medical Journal of China Primary Topic Heart Secondary TopicAging Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Conclusion: Hydrogen-rich saline can attenuate myocardial reperfusion injury through inhibiting cardiomyocyte autophagy. The mechanism may be associated with decreasing the expression of AMPK, mTOR, Beclin1, LC3 in myocardial tissue.