General Research
Model: human
Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity
Simplified Version Available
Hydrogen Therapy: A New Way to Reduce Oxidative Stress in Dialysis Patients
Researchers in Japan have found that dissolved hydrogen can reduce oxidative stress in peritoneal dialysis patients. This breakthrough has implications for various medical treatments and could lead to new therapies. Hydrogen water can even be made at home using water ionizers or hydrogen generators.
Read Simplified ArticleAbstract
Publish Year 2013 Country Japan Rank Positive Journal Medical Gas Research Primary Topic Peritonium Secondary TopicPeritoneal Dialysis Model Human Tertiary TopicOxidative Stress Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Methods: Effluent and blood samples of 6 regular PD patients were obtained during the peritoneal equilibrium test using standard dialysate and hydrogen-enriched dialysate. The redox state of albumin in effluent and blood was determined using high-performance liquid chromatography.
Methods
Results: Mean proportion of reduced albumin (ƒ(HMA)) in effluent was significantly higher in H2-enriched dialysate (62.31 ± 11.10%) than in standard dialysate (54.70 ± 13.08%). Likewise, serum ƒ(HMA) after administration of hydrogen-enriched dialysate (65.75 ± 7.52%) was significantly higher than that after standard dialysate (62.44 ± 7.66%). Conclusions: Trans-peritoneal administration of H2 reduces peritoneal and systemic OS.