General Research
Model: mouse
Therapeutic Effects of Hydrogen-Rich Solution on Aplastic Anemia in Vivo
Simplified Version Available
Healing Power of Hydrogen: New Hope for Aplastic Anemia
A 2013 study found that hydrogen-rich solutions can help improve blood cell production in mice with aplastic anemia, a rare blood disorder. Hydrogen therapy has antioxidant properties that protect cells and promote healing. This breakthrough offers new hope for people living with aplastic anemia and could lead to new treatments.
Read Simplified ArticleAbstract
Publish Year 2013 Country China Rank Positive Journal Cellular Physiology and Biochemistry Primary Topic Bone Marrow Secondary TopicImmune Dysfunction Model Mouse Tertiary TopicAplastic Anemia Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Methods: AA model was determined in vivo by mice and body weights of the mice were used as the basic physiological index. Peripheral blood cells were calculated to evaluate the hematologic recovery degree. Bone marrow nucleated cells (BMNCs), tissue histology, as well as CFU-S and CFU-GM forming units were used to evaluate the recovery of bone marrow microenvironment. The ratio of CD4(+) and CD8(+) cells were examined along with cytokine levels in serum to determine the efficacy of H2-rich solution on the affected immunological functions.
Methods
Results: Body weight and number of peripheral blood cells were significantly improved for mice in the H2-rich solution treated groups as compared with those with AA. The number of BMNCs and CFUs increased markedly and the bone marrow microenvironment was also improved significantly. The experimental group restrained the cell apoptosis, relieved hyperemia and accelerated tissue repair. The number of CD4(+) and CD8(+) cells as well as the ratio of CD4/CD8 increased to normal gradually, while the levels of TNF-α, IFN-γ, and IL-6 in serum decreased after H2-rich solution treatment.
Results
Conclusion: Our study firstly showed that hydrogen-rich solution accelerated the recovery of either hematological or immunological recovery on aplastic anemia mice. This finding suggests hydrogen-rich solution as a potential clinical therapeutic agent for AA. © 2013 S. Karger AG, Basel.