General Research
Model: rabbit
The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest
Simplified Version Available
How Hydrogen May Protect the Brain After Cardiac Arrest
A study on rabbits found that hydrogen injections may protect the brain after cardiac arrest by reducing oxidative stress. This could lead to new treatments for cardiac arrest patients. The use of hydrogen in medical treatments is a promising area of research with potential applications beyond cardiac arrest.
Read Simplified ArticleAbstract
Publish Year 2013 Country China Rank Positive Journal Resuscitation Primary Topic Brain Secondary TopicCardiac Arrest Model Rabbit Tertiary TopicHypoxia-Ischemia Vehicle Gas pH N/A Application Injection Comparison Complement
Methods
Results: Intraperitoneal injection of H2 improved the 72-h survival rate and neurological scores, reduced neuronal injury and inhibited neuronal apoptosis. Intraperitoneal injection of H2 reduced oxidative stress indicators in the plasma and hippocampal tissues and enhanced antioxidant enzyme activity. No significant difference was observed between the two CA groups treated with different doses of H2. Conclusions: Intraperitoneal injection of H2 is a novel hydrogen administration method and can reduce cerebral ischemia-reperfusion injury and improve the prognosis of cardiopulmonary cerebral resuscitation in a rabbit model of CA.