General Research
Model: human
Influence of oxygen concentration on the neuroprotective effect of hydrogen inhalation in a rat model of cardiac arrest
Simplified Version Available
How Hydrogen Inhalation Can Help Protect Your Brain After Cardiac Arrest
A recent study found that hydrogen inhalation can help protect the brain from damage after cardiac arrest, especially when oxygen levels are low. This discovery could lead to new treatments for cardiac arrest and other conditions. Researchers are also exploring hydrogen's potential to treat lung disease, chronic fatigue syndrome, and liver damage.
Read Simplified ArticleAbstract
Publish Year 2022 Country China Rank Positive Journal Frontiers in Neurology Primary Topic Brain Secondary TopicCardiac Arrest Model Rat Tertiary TopicHypoxia-Ischemia Vehicle Gas pH N/A Application Inhalation Comparison Complement Oxygen
Background
Methods: Cardiopulmonary resuscitation (CPR) was initiated after 7 min of untreated VF in adult male Sprague-Dawley rats. Immediately following successful resuscitation, animals were randomized to be ventilated with 21% oxygen and 79% nitrogen (21%O2); 2% hydrogen, 21% oxygen, and 77% nitrogen (2%H2 + 21%O2); 2% hydrogen, 50% oxygen, and 48% nitrogen (2%H2 + 50%O2); or 2% hydrogen and 98% oxygen (2%H2 + 98%O2) for 3 h. For each group, the target temperature was 37.5°C for half of the animals and 35.0°C for the other half.
Methods
Results: No statistical differences in baseline measurements and CPR characteristics were observed among groups. For animals with normothermia, 2%H2 + 50%O2 (123 [369] vs. 500 [393], p = 0.041) and 2%H2 + 98%O2 (73 [66] vs. 500 [393], p = 0.002) groups had significantly lower neurological deficit scores (NDSs) at 96 h and significantly higher survival (75.0 vs. 37.5%, p = 0.033 and 81.3 vs. 37.5%, p = 0.012) than 21%O2 group. For animals with hypothermia, no statistical difference in NDS among groups but 2%H2 + 98%O2 has significantly higher survival than the 21%O2 group (93.8 vs. 56.3%, p = 0.014).
Results
Conclusion: In this CA rat model, inhaling 2% hydrogen combined with a high concentration of oxygen improved 96-h survival, either under normothermia or under hypothermia.