General Research
Model: human
Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water
Simplified Version Available
Can Electrolyzed Water Reduce Oxidative Stress in Dialysis Patients?
A 2003 study found that electrolyzed reduced water can reduce oxidative stress in end-stage renal disease patients. This is exciting news for people on dialysis, as it could help them feel better and improve their overall health. Electrolyzed water works by neutralizing free radicals in the body, reducing oxidative stress.
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Publish Year 2003 Country Taiwan Rank Positive Journal Kidney International Primary Topic Kidney Secondary TopicHaemodialysis Model Human Tertiary TopicOxidative Stress Vehicle Water (Electrolysis) pH Alkaline Application Injection Comparison Complement
Background
Methods: We developed a chemiluminescence emission spectrum and high-performance liquid chromatography analysis to assess the effect of ERW replacement on plasma ROS (H2O2 and HOCl) scavenging activity and oxidized lipid or protein production in ESRD patients undergoing hemodialysis. Oxidized markers, dityrosine, methylguanidine, and phosphatidylcholine hydroperoxide, and inflammatory markers, interleukin 6 (IL-6), and C-reactive protein (CRP) were determined.
Methods
Results: Although hemodialysis efficiently removes dityrosine and creatinine, hemodialysis increased oxidative stress, including phosphatidylcholine hydroperoxide, and methylguanidine. Hemodialysis reduced the plasma ROS scavenging activity, as shown by the augmented reference H2O2 and HOCl counts (Rh2o2 and Rhocl, respectively) and decreased antioxidative activity (expressed as total antioxidant status in this study). ERW administration diminished hemodialysis-enhanced Rh2o2 and Rhocl, minimized oxidized and inflammatory markers (CRP and IL-6), and partly restored total antioxidant status during 1-month treatment.
Results
Conclusion: This study demonstrates that hemodialysis with ERW administration may efficiently increase the H2O2- and HOCl-dependent antioxidant defense and reduce H2O2- and HOCl-induced oxidative stress.