General Research Model: mouse

Radio-protective effect of hydrogen rich water combined with amifostine in mice

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Staying Safe from Radiation: How Hydrogen-Rich Water and Amifostine Can Help

A 2016 study found that hydrogen-rich water and amifostine can protect mice from radiation damage. This combination could lead to new ways to keep people safe during medical treatments or emergencies. More research is needed, but this is a promising step towards radiation protection.

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Abstract

Publish Year 2016 Country China Rank Positive Journal International Journal of Radiation Research Primary Topic Whole Body Secondary TopicCancer Model Mouse Tertiary TopicRadioprotection Vehicle Water (Dissolved) pH Neutral Application Ingestion Comparison Complement

Background

Methods: Male ICR mice were treated intragastrically with HRW or/and intraperitoneally with AM 30 minutes prior to 9.0 Gy whole body irradiation from a⁶⁰Co source (dose rate 0.96Gy/min). Then the survival rate for 30 days, the hematological parameters, the Clinical chemistry parameters and the bone marrow nucleated cells were examined.

Methods

Results: We found that the mice treated with HRW and AM before irradiaion could increase the 30-day survival rate and improve the body weight better than the HRW or AM treatment alone group and irradiaion alone group. Hematological test and Clinical chemistry assays also showed the same results that HRW combined AM could beter improve the recovery of hemopoietic system and alleviate the detrimental effects of radiation.