General Research
Model: rat
Protective effects of hydrogen-rich saline on ulcerative colitis rat model
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Hydrogen-Rich Saline: A Potential Breakthrough for Ulcerative Colitis Treatment
A 2013 study found that hydrogen-rich saline reduced inflammation and improved symptoms in rats with ulcerative colitis. This promising research suggests that hydrogen-rich saline could be a useful treatment for humans with the condition. More research is needed, but the anti-inflammatory properties of hydrogen gas offer hope for new and effective treatments.
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Publish Year 2013 Country China Rank Positive Journal Journal of Surgical Research Primary Topic Intestine Secondary TopicInflammatory Bowel Disease Model Rat Tertiary TopicUlcerative Colitis Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Materials and methods: UC in rats was induced with intracolonically administrated acetic acid. Hydrogen was supplied through intraperitoneal injection of 10 or 20 mL/kg hydrogen-rich saline. The hydrogen treatment was performed once every 2 d and lasted 2 wk. The stool consistency and weight loss were used to evaluate UC development. Colonic mucosal damage at the end of the experiment was scored using the macroscopic and microscopic observations. Vascular endothelial growth factor expression in the colonic mucosa was determined using immunohistochemistry.