General Research Model: rat

Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury

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How Hydrogen-Rich Saline May Help Protect Lungs from Smoke Damage

A study on rats found that hydrogen-rich saline may help protect lungs from smoke damage. The research suggests that hydrogen-rich saline could be a useful treatment for people who have inhaled smoke. This could have implications for people who work in jobs where they are exposed to smoke, such as firefighters or construction workers.

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Abstract

Publish Year 2015 Country China Rank Positive Journal Oxidative Medicine and Cellular Longevity Primary Topic Lung Secondary TopicEnvironmental Pollution Model Rat Tertiary TopicWood Smoke Exposure Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement

Methods

Results: Tumor necrosis factor-alpha (TNF-α) levels, malondialdehyde (MDA) concentrations, nuclear factor kappa B (NF-κB) p65 expression, and apoptosis index (AI) in I+HS group were significantly decreased (P < 0.05), while superoxide dismutase (SOD) activities were increased compared with those in I+NS group; and a marked improvement in alveolar structure was also found after hydrogen-rich saline treatment. Conclusions: Hydrogen-rich saline treatment exerts protective effects in acute lung injury induced by inhalation injury, at least in part through the activation of anti-inflammatory and antioxidant pathways and inhibition of apoptosis.