General Research
Model: pig
Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study
Simplified Version Available
How Hydrogen Gas Inhalation Can Protect Your Hearing from Loud Noises
A recent study found that inhaling hydrogen gas before exposure to loud noises can reduce hearing loss. Hydrogen gas has antioxidant properties that help protect the delicate hair cells in our ears. This discovery could be a game-changer for people who work in noisy environments or enjoy loud music.
Read Simplified ArticleAbstract
Publish Year 2022 Country Sweden Rank Positive Journal Annals of Otology, Rhinology, and Laryngology Primary Topic Ear Secondary TopicEnvironmental Pollution Model Guinea Pig Tertiary TopicNoise Pollution Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: Noise exposure caused ABR threshold elevations at all frequencies (median 35, 35, 30, 35, and 35 dB SPL, the Noise group; 20, 25, 10, 13, and 20 dB SPL, the Noise + H2 group; P < .05) but significantly less so in the Noise + H2 group (P < .05). Outer hair cell (OHC) loss was in the apical, mid, and basal regions 8.8%, 53%, and 14% in the Noise group and 3.5%, 22%, and 1.2% in the Noise + H2 group. The corresponding inner hair cell (IHC) loss was 0.1%, 14%, and 3.5% in the Noise group and 0%, 2.8%, and 0% in the Noise + H2 group. The difference between the groups was significant in the basal region for OHCs (P = .003) and apical (P = .033) and basal (P = .048) regions for IHCs. Conclusions: Acute acoustic trauma can be reduced by H2 when inhaled immediately after impulse noise exposure. Keywords: auditory brainstem response; auditory hair cell; guinea pig; hearing loss; molecular hydrogen; noise-induced; otoprotection.