General Research
Model: human
Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis
Simplified Version Available
Healing with Hydrogen: A New Approach to Treating Peritonitis
Researchers have found that using hydrogen-rich saline for peritoneal lavage can be an effective treatment for acute peritonitis, a serious condition causing inflammation of the abdominal cavity lining. This approach harnesses the antioxidant properties of hydrogen to reduce inflammation and promote healing. The study's findings offer a potential new, relatively safe, and non-invasive treatment option for peritonitis.
Read Simplified ArticleAbstract
Publish Year 2021 Country Japan Rank Positive Journal Surgery Today Primary Topic Peritonium Secondary TopicSepsis Model Rat Tertiary TopicPeritonitis Vehicle Saline (Dissolved) pH Neutral Application Irrigation Comparison Complement
Methods
Results: Peritoneal lavage with HRS significantly improved the survival after CLP in rats, and it ameliorated the levels of sepsis-induced organ failure. Moreover, it showed anti-inflammatory and anti-apoptosis as well as antioxidant effects. The second experiment demonstrated the potential safety and feasibility of this procedure in a large animal model.
Results
Conclusion: This procedure can improve survival after sepsis through mitigating the sepsis-induced organ failure by inhibiting oxidative stress, apoptosis, and inflammatory pathways. Peritoneal lavage with HRS may therefore be an effective, safe, and practical therapy for patients with acute peritonitis.
Purpose
Methods: Two experiments were performed. In the first experiment, we confirmed the effects of peritoneal lavage with hydrogen-rich saline (HRS) after a cecal ligation and puncture (CLP) operation in rats. In the second experiment, the changes in the hemodynamic state following this procedure were observed in a porcine model of abdominal sepsis to evaluate its safety and utility.