General Research
Model: rat
Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early Brain Injury following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3β Signaling Pathway
Simplified Version Available
How Hydrogen-Rich Saline May Help Prevent Brain Damage After Injury
Researchers in China have found that hydrogen-rich saline may help reduce brain damage after an injury by protecting cells and promoting survival. The study used rats with brain injuries and found promising results. This breakthrough could have significant implications for the treatment and recovery of brain injuries, and may even have applications beyond.
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Publish Year 2014 Country China Rank Positive Journal PLoS One Primary Topic Brain Secondary TopicBrain Injury Model Rat Tertiary TopicIntracranial Hemorrhage Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: HS significantly reduced neuronal apoptosis and improved neurological function at 24 hours after SAH. The levels of pAkt and pGSK3β, mainly expressed in neurons, were markedly up-regulated. Additionally, Bcl-2 was significantly increased while Bax and cleaved caspase-3 was decreased by HS treatment. Double staining of pAkt and TUNEL showed few colocalization of pAkt-positive cells and TUNEL-positive cells. The inhibitor of PI3K, Ly294002, suppressed the beneficial effects of HS. Conclusions: HS could attenuate neuronal apoptosis in EBI and improve the neurofunctional outcome after SAH, partially via the Akt/GSK3β pathway.