General Research
Model: in_vitro
Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of Mitochondria
Simplified Version Available
How Hydrogen Gas Can Help Turn Fat Cells into Muscle
A recent study found that hydrogen gas can help convert fat cells into muscle cells by regulating mitochondria. This breakthrough has significant implications for muscle growth and repair, and may lead to new therapies for various medical applications. Hydrogen gas may also be useful in combination with other therapies to promote overall health and wellness.
Read Simplified ArticleAbstract
Publish Year 2022 Country China Rank Positive Journal Current Stem Cell Research & Therapy Primary Topic Whole Body Secondary TopicHydrogen Biology Model Cell Culture Tertiary TopicStem Cell Differentiation Vehicle Gas pH N/A Application Ventilation Comparison Complement
Background
Methods: The protective effects of H2 in ADSCs were evaluated by MTT assay, live-dead cell staining, western blot analysis, immunofluorescence staining, confocal imaging, and transmission electron microscopy.
Methods
Results: An appropriate volume fraction of H2 significantly decreased mitochondrial reactive oxygen species (ROS) levels, increased the number of mitochondria, and promoted mitophagy, thus enhancing the survival and myogenic differentiation of ADSCs.
Results
Conclusion: This study reveals the application potential of H2 in skeletal muscle diseases or other pathologies related to mitochondrial dysfunction.