General Research
Model: human
Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans
Simplified Version Available
How Hydrogen Water Affects Brain Chemistry in Overweight Individuals
A recent study explored the effects of hydrogen water on brain chemistry in overweight individuals, finding that it may help regulate hunger signals and support weight management. The study's findings suggest that hydrogen water could be a useful tool for those looking to lose weight or improve their overall health. More research is needed to fully understand its effects.
Read Simplified ArticleAbstract
Publish Year 2023 Country Serbia Rank Positive Journal Archives of Medical Science Primary Topic Brain Secondary TopicObesity Model Human Tertiary TopicHunger Suppression Vehicle Water, Commercial (Natural Health Products) pH Neutral Application Ingestion Comparison Complement
Methods
Results: The mean glutamate and glutamate-plus-glutamine levels at the posterior cingulate gyrus decreased significantly during the study; this was accompanied by a significant drop in GABA levels at left prefrontal white matter, and glutathione levels at anterior cingulate gyrus. No changes in the brain metabolites were found in the comparable group of overweight individuals (n = 4, 2 women; age: 41.0 ±13.9, BMI 26.8 ±1.3 kg/m2) followed-up in the past without this treatment. Conclusions: We showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss. Further studies analyzing appetite-controlling metabolic pathways affected by H2 would require monitoring of additional biomarkers of satiation and satiety during different feeding regimens.