General Research
Model: human
Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway
Simplified Version Available
Hydrogen Gas: A New Hope in the Fight Against Colorectal Cancer?
A recent study from China found that hydrogen gas inhalation can slow down colorectal cancer growth in mice. The gas works by blocking a signaling pathway that cancer cells use to grow. This research is promising and could lead to new treatments for colorectal cancer. Hydrogen gas is also being studied for its potential to help with other health issues.
Read Simplified ArticleAbstract
Publish Year 2022 Country China Rank Positive Journal BioMed Research International Primary Topic Intestine Secondary TopicCancer Model Mouse Tertiary TopicNovel Therapy Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: Hydrogen treatment suppressed the proliferation of CRC cell lines independent of apoptosis, and the cell lines showed different responses to different doses of H2. Hydrogen also elicited a potent antitumor effect to reduce CRC tumor volume and weight in vivo. Western blot and IHC staining demonstrated that H2 inhibits CRC cell proliferation by decreasing pAKT/SCD1 levels, and the inhibition of cell proliferation induced by H2 was reversed by the AKT activator SC79. IHC showed that SCD1 expression was significantly higher in CRC tissues than in normal epithelial tissues (70.3% vs. 29.7%, p = 0.02) and was correlated with a more advanced TNM stage (III vs. I + II; 75.9% vs. 66.3%, p = 0.02), lymph node metastasis (with vs. without; 75.9% vs. 66.3%, p = 0.02), and patients without a family history of CRC (78.7% vs. 62.1%, p = 0.047).
Results
Conclusion: This study demonstrates that high concentrations of H2 exert an inhibitory effect on CRC by inhibiting the pAKT/SCD1 pathway. Further studies are warranted for clinical evaluation of H2 as SCD1 inhibitor to target CRC.