General Research
Model: in_vitro
Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous solutions
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How Hydrogen Can Help Protect Your DNA from Radiation Damage
Scientists have discovered that molecular hydrogen can help protect DNA from radiation damage. In a 2016 study, French researchers found that hydrogen-treated cells showed less DNA damage than cells without hydrogen. This breakthrough could lead to new ways to protect ourselves from radiation, which we're all exposed to every day.
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Publish Year 2016 Country France Rank Positive Journal International Journal of Radiation Biology Primary Topic Whole Body Secondary TopicRadioprotection Model Cell Culture Tertiary TopicGamma Radiation Vehicle Water (Dissolved) pH Neutral Application Culture Media Comparison Helium Complement
Purpose
Materials and methods: Aerated aqueous solutions of calf thymus DNA were exposed to a (60)Co source at doses ranging from 0 to 55 Gy under normoxic conditions, in the presence or not of 0.7 MPa hydrogen or helium. The measurement of several modified bases was performed using HPLC associated with electrospray ionization tandem pass spectrometry (HPLC-ESI-MS/MS). Bleaching of aqueous solutions of p-nitrosodimethylaniline (p-NDA) solutions was also used to allow the quantification of hydroxyl radical (•OH) formation.