General Research
Model: pig
Low-Flow Nasal Cannula Hydrogen Therapy
Simplified Version Available
Breathing Easy: How Hydrogen Therapy May Improve Our Health
A 2020 study published in the Journal of Clinical Medical Research found that low-flow nasal cannula hydrogen therapy was safe and well-tolerated in pigs. Hydrogen therapy may be a promising treatment for various conditions by reducing inflammation and promoting healing. More research is needed to fully understand its benefits.
Read Simplified ArticleAbstract
Publish Year 2020 Country Japan Rank Neutral Journal Journal of Clinical Medical Research Primary Topic Whole Body Secondary TopicHydrogen Biology Model Pig Tertiary TopicHydrogen Safety Vehicle Gas pH N/A Application Inhalation Comparison Complement
Background
Methods: We administered 100% H2, produced by an H2 gas generator, at a low-flow rate of 250 mL/min via a nasal cannula to three spontaneously breathing micro miniature pigs. An oxygen mask was placed over the nasal cannula to administer oxygen while minimizing H2 leakage, and a catheter was inserted into the carotid artery to monitor the arterial blood H2 concentration.
Methods
Results: During the first hour of H2 inhalation, the mean (standard error (SE)) H2 concentrations and saturations in the arterial blood of the three pigs were 1,560 (413) nL/mL and 8.85% (2.34%); 1,190 (102) nL/mL and 6.74% (0.58%); and 1,740 (181) nL/mL and 9.88% (1.03%), respectively. These values are comparable to the concentration one would expect if 100% of the H2 released from the H2 gas generator is taken up by the body. Conclusions: Inhalation of 100% H2 produced by an H2 gas generator, even at low-flow rates, can increase blood H2 concentrations to levels that previous non-clinical and clinical studies demonstrated to be therapeutically effective. The combination of a nasal cannula and an oxygen mask is a convenient way to reduce H2 leakage while maintaining oxygenation.