General Research
Model: mouse
Intraperitoneally administered, hydrogen-rich physiologic solution protects against postoperative ileus and is associated with reduced nitric oxide production
Simplified Version Available
How Hydrogen-Rich Solutions Can Help Prevent Postoperative Ileus
A study in Japan found that hydrogen-rich solution can help prevent postoperative ileus, a common complication after surgery. The solution reduced nitric oxide production and alleviated symptoms in rats. This breakthrough could lead to new treatments for postoperative ileus and improve recovery times for patients.
Read Simplified ArticleAbstract
Publish Year 2016 Country Japan Rank Positive Journal Surgery Primary Topic Intestine Secondary TopicSurgery/Transplantation Model Rat Tertiary TopicPostoperative Ileus Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Methods: Ileus was induced via surgical manipulation in mice and rats. The peritoneal cavity was filled with 1.0 mL saline or hydrogen-rich saline (≥1.5-2.0 ppm) before closure of the abdominal incision. Intestinal transit was assessed 24 hours postoperatively. Inflammation was examined by quantitation of neutrophil extravasation and expression of proinflammatory markers. Nitric oxide production was assessed in cultured muscularis propria.
Methods
Results: Surgical manipulation resulted in a marked delay in intestinal transit and was associated with upregulation of proinflammatory cytokines and increased neutrophil extravasation. Bowel dysmotility, induced by surgical manipulation and inflammatory events, was significantly attenuated by intra-abdominal administration of hydrogen-rich saline. Nitric oxide production in the muscle layers of the bowel was inhibited by hydrogen treatment.
Results
Conclusion: A single intraperitoneal dose of hydrogen-rich saline ameliorates postoperative ileus by inhibiting the inflammatory response and suppressing nitric oxide production.