General Research
Model: mouse
Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice
Simplified Version Available
Hydrogen Water: A Natural Solution for Soothing Atopic Dermatitis
A 2017 study found that hydrogen water reduced the severity of atopic dermatitis-like lesions in mice. The water decreased inflammation and mast cell infiltration, which can lead to itching and redness. While more research is needed, hydrogen water may offer a natural solution for soothing atopic dermatitis symptoms.
Read Simplified ArticleAbstract
Publish Year 2017 Country Japan Rank Positive Journal Saudi Medical Journal Primary Topic Skin Secondary TopicDermatitis Model Mouse Tertiary TopicImmune Dysfunction Vehicle Water (Electrolysis) pH Alkaline Application Ingestion Comparison Complement
Methods
Results: Mice treated with HW for 4 weeks demonstrated a significant decrease in the AD severity score compared with PW-treated mice (p less than 0.01). Hydrogen water administration also significantly reduced TEWL and serum TARC levels (p less than 0.01), infiltration of mast cells (p less than 0.05), and secretion of the proinflammatory cytokines interleukin (IL)-1β and IL-33 (p less than 0.05) in skin lesions compared with PW. However, no difference was observed between PW and HW groups in interferon-γ secretion and expression of AQP-3 and TARC genes.
Results
Conclusion: Hydrogen water suppressed inflammation in AD mice, leading to amelioration of disease severity, which suggests the therapeutic potential of HW in AD treatment.