General Research
Model: human
Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression
Simplified Version Available
How Hydrogen Water Helps Protect Lungs from Pollution Damage
Hydrogen water may help protect lungs from pollution damage by enhancing Nrf2 expression, a protein that reduces cell harm. A recent study found that hydrogen water reduced damage to lung fibroblasts caused by the pesticide paraquat. This breakthrough could lead to new ways to protect our lungs from pollution and other diseases.
Read Simplified ArticleAbstract
Publish Year 2020 Country China Rank Positive Journal Journal of Southern Medical University Primary Topic Lung Secondary TopicEnvironmental Pollution Model Cell Culture Tertiary TopicPesticide Toxicity (Paraquat) Vehicle Water (Dissolved) pH Neutral Application Culture Media Comparison Complement
Methods
Results: Compared with the PQ-exposed cells, the cells with hydrogen water treatment showed significantly lowered expressions of Col-I, Col-III, and α-SMA. Interference of Nrf2 expression obviously attenuated the effect of hydrogen water on PQ-exposed cells. Hydrogen water treatment significantly increased the expression of Nrf2 and promoted the production of the antioxidants in PQ-exposed lung fibroblasts. Conclusions: Hydrogen water enhances Nrf2 expression to promote the proliferation and production of antioxidants and inhibit the differentiation and collagen secretion in PQ-exposed human lung fibroblasts in vitro.