General Research
Model: rat
Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia
Simplified Version Available
How Hydrogen May Help Reduce Pregnancy Complications Like Preeclampsia
A recent study found that hydrogen therapy may help reduce oxidative stress in preeclampsia by inhibiting the p38 MAPK signaling pathway. This breakthrough could lead to new treatments for pregnant women and improve health outcomes for moms and babies. More research is needed to confirm these findings, but the potential benefits of hydrogen therapy are promising.
Read Simplified ArticleAbstract
Publish Year 2022 Country China Rank Positive Journal Advances in Clinical and Experimental Medicine Primary Topic Pregnancy Secondary TopicPreeclampsia Model Rat Tertiary TopicOxidative Stress Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Results: It was found that hydrogen-rich saline (LH group) decreased placental MDA, proteinuria, TNF-α, and IL-1β levels in the placental tissues compared with the L group (all p < 0.05). Additionally, hydrogen-rich saline (LH group) treatment significantly decreased the p38 MAPK mRNA expression and p-p38 MAPK protein levels compared with the L group (p < 0.05). The p38 MAPK inhibitor SB203580 (LHS group) further decreased the p38 MAPK mRNA expression and p-p38 MAPK protein levels compared with the LH group (p < 0.05). Conclusions: Hydrogen can decrease the reactive oxygen species (ROS) content and inhibit the MAPK pathway. The protective effect of hydrogen may be associated with the inhibition of the p38 MAPK signaling pathway.