General Research
Model: in_vitro
Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells
Simplified Version Available
How Vitamins and Hydrogen Impact Pregnancy Health
A study found that molecular hydrogen, vitamins C and E can help reduce oxidative stress and improve placental function in pregnancy. This is exciting news for pregnant women, as it may help prevent problems like preeclampsia. By understanding how these antioxidants work, we can better support pregnant women and promote healthy pregnancies.
Read Simplified ArticleAbstract
Publish Year 2015 Country China Rank Positive Journal Archives of Gynecology and Obstetrics Primary Topic Pregnancy Secondary TopicPreeclampsia Model Cell Culture Tertiary TopicOxidative Stress Vehicle Medium (Dissolved) pH Neutral Application Culture Media Comparison Vitamin C; Vitamin E Complement
Methods
Results: Cell viability was significantly suppressed by 500 μmol/L vitamins C and E (P 0.05). The expression of TNF-α was increased by 100 μmol/L vitamin C and 50 μmol/L vitamins E, separately or combined (P < 0.05), but not by molecular hydrogen (0-500 μmol/L), as validated by real-time RT-PCR. But the secretion of hCG was both inhibited by 50-500 μmol/L molecular hydrogen and high levels of vitamin C and E, separately or combined.
Results
Conclusion: High levels of antioxidant vitamins C and E may have significant detrimental effects on placental function, as reflected by decreased cell viability and secretion of hCG; and placental immunity, as reflected by increased production of TNF-a. Meanwhile hydrogen showed no such effects on cell proliferation and TNF-α expression, but it could affect the level of hCG, indicating hydrogen as a potential candidate of antioxidant in the management of preeclampsia (PE) should be further studied.