General Research Model: mouse

Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora dysbiosis in DSS-induced chronic ulcerative colitis mice

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Can Hydrogen-Rich Water Help Soothe Inflamed Digestive Issues?

A recent study found that hydrogen-rich water helped reduce inflammation and oxidative stress in mice with chronic ulcerative colitis. This could lead to new treatments for people with the condition. Hydrogen-rich water has anti-inflammatory and antioxidant effects, making it a promising area of research.

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Abstract

Publish Year 2021 Country China Rank Positive Journal Advances in Medical Sciences Primary Topic Intestine Secondary TopicInflammatory Bowel Disease Model Mouse Tertiary TopicUlcerative Colitis Vehicle Water (Dissolved) pH Neutral Application Ingestion Comparison Complement

Purpose

Materials and methods: Male C57BL/6 mice (19.6 ± 0.4 g, 7 weeks) were randomly divided into 3 groups: normal control (NC) group, UC (Dextran Sulfate Sodium, DSS) group, and hydrogen-rich water (HRW, 0.8 ppm)-treated UC (DSS + HRW) group. Mice in the DSS treatment group were treated with DSS for the following 3 cycles to establish chronic UC model: the first 2 cycles consisted of 2.5% DSS for 5 days, followed by drinking water for 16 days, and a third cycle consisted of 2% DSS for 4 days, followed by drinking water for 10 days. The mice in the DSS + HRW group were administered HRW daily throughout the experiment.