General Research
Model: mouse
Hydrogen rich water ameliorate Trimethyltin induced spatial learning and memory impairment by regulation of Siah-1
Simplified Version Available
How Hydrogen-Rich Water May Help Protect Your Brain from Pollution
A recent study found that hydrogen-rich water can help protect the brain from damage caused by pollutants like Trimethyltin. The water helps a protein called Siah-1 work better, which allows the brain to get rid of bad stuff and stay healthy. This could be a simple way to give our brains a little extra protection from pollution.
Read Simplified ArticleAbstract
Publish Year 2020 Country China Rank Positive Journal Research Square Primary Topic Brain Secondary TopicEnvironmental Pollution Model Mouse Tertiary TopicPesticide Toxicity (Trimethyltin) Vehicle Water (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Methods: Male BALB/c mice were randomly divided into 4 groups: control group (saline, 4 ml/d, i.p.for seven days), HRW group (4 ml/d, i.p.for seven days) , TMT group (2.25mg/kg, i.p. at the seventh day ), and HRW plus TMT group. The spatial learning and memory was tested by Morris water maze, the protein level of SYP and Siah-1were determined by western blot& immunocytochemical analysis, and the tin contents were detected by ICP-MS.
Methods
Results: The TMT-treated mice showed significant learning and memory disability. Moreover, TMT increased the level of Siah-1, reduced the expression of SYP in hippocampus and cortex. After 7 days of continuous pretreatment with HRW, the mice showed better memory ability, the expression of Siah-1 and tin content decreased accompanied with the increase of SYP. Conclusions: These results showed that HRW ameliorated the decrease of SYP and the nerve impairment induced by TMT, reduced tin content and up-regulated the expressions of Siah-1, and it might be an important role in the protection of neurodegenerative diseases induced by TMT.