General Research
Model: rabbit
Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits
Simplified Version Available
Hydrogen Water: A Promising Solution for Brain Injury Recovery
A study found that hydrogen-rich saline reduced oxidative stress and brain edema in rabbits with subarachnoid hemorrhage. This could lead to new treatments for brain injuries. Drinking hydrogen water, made at home with a water ionizer, may also have benefits for overall health.
Read Simplified ArticleAbstract
Publish Year 2012 Country China Rank Positive Journal BMC Neuroscience Primary Topic Brain Secondary TopicBrain Injury Model Rabbit Tertiary TopicIntracranial Hemorrhage Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Results: The level of MDA, caspase-12/3 and brain water content increased significantly at 72 hours after experimental SAH. Correspondingly, obvious brain injury was found in the SAH group by terminal deoxynucleotidyl transferase-mediated uridine 5'-triphosphate-biotin nick end-labeling (TUNEL) and Nissl staining. Similar results were found in the SAH+saline group. In contrast, the upregulated level of MDA, caspase-12/3 and brain edema was attenuated and the brain injury was substantially alleviated in the hydrogen treated rabbits, but the improvement of neurology outcome was not obvious.
Results
Conclusion: The results suggest that treatment with hydrogen in experimental SAH rabbits could alleviate brain injury via decreasing the oxidative stress injury and brain edema. Hence, we conclude that hydrogen possesses the potential to be a novel therapeutic agent for EBI after SAH.