General Research
Model: mouse
Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage
Simplified Version Available
Hydrogen Water: A Potential Game-Changer for Brain Injury Treatment
A recent study found that hydrogen-rich saline can alleviate early brain injury after subarachnoid hemorrhage by regulating ER stress and autophagy. This breakthrough could lead to new treatments for brain injuries. Hydrogen water, which can be made at home, shows promise in medical research, potentially revolutionizing the treatment of various conditions.
Read Simplified ArticleAbstract
Publish Year 2021 Country China Rank Positive Journal Acta Cirurgica Brasileira Primary Topic Brain Secondary TopicBrain Injury Model Mouse Tertiary TopicIntracranial Hemorrhage Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: The results show that hydrogen-rich saline treatment markedly increased the survival rate and neurological score, increased neuron survival, downregulated the autophagy protein expression of Beclin-1 and LC3, and endoplasmic reticulum (ER) stress. That indicates that hydrogen-rich saline-mediated inhibition of autophagy and ER stress ameliorate neuronal death after SAH. The neuroprotective capacity of hydrogen-rich saline is partly dependent on the ROS/Nrf2/heme oxygenase-1 (HO-1) signaling pathway. Conclusions: The results of this study demonstrate that hydrogen-rich saline improves neurological outcomes in mice and reduces neuronal death by protecting against neural autophagy and ER stress.
Purpose
Methods: In the present study, the objective was to investigate the neuroprotective effects and potential molecular mechanisms of hydrogen-rich saline in SAH-induced EBI by regulating neural autophagy in the C57BL/6 mice model. Mortality, neurological score, brain water content, ROS, malondialdehyde (MDA), and neuronal death were evaluated.