General Research
Model: human
Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
Simplified Version Available
Breathing Easier: How Hydrogen-Oxygen Therapy May Help COPD Symptoms
A new study in China found that hydrogen-oxygen therapy may help people with COPD breathe easier. The treatment involves inhaling a mix of hydrogen and oxygen gases, which can reduce inflammation in the lungs. The results are promising, and this therapy could become a new tool for managing COPD symptoms.
Read Simplified ArticleAbstract
Publish Year 2021 Country China Rank Positive Journal Respiratory Research Primary Topic Lung Secondary TopicChronic Obstructive Pulmonary Disease Model Human Tertiary TopicInflammation Vehicle Gas pH N/A Application Inhalation Comparison Oxygen Complement
Background
Methods: This prospective, randomized, double-blind, controlled clinical trial in 10 centres enrolled patient with AECOPD and a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 6 points. Eligible patients were randomly assigned (in a 1:1 ratio) to receive either hydrogen/oxygen mixture or oxygen therapy. Primary endpoint was the change from baseline in BCSS score at day 7. Adverse events (AEs) were recorded to evaluate safety.
Methods
Results: Change of BCSS score in Hydrogen/oxygen group was larger than that in Oxygen group (- 5.3 vs. - 2.4 point; difference: - 2.75 [95% CI - 3.27 to - 2.22], meeting criteria for superiority). Similar results were observed in other time points from day 2 through day 6. There was a significant reduction of Cough Assessment Test score in Hydrogen/oxygen group compared to control (- 11.00 vs. - 6.00, p < 0.001). Changes in pulmonary function, arterial blood gas and noninvasive oxygen saturation did not differ significantly between groups as well as other endpoints. AEs were reported in 34 (63.0%) patients in Hydrogen/oxygen group and 42 (77.8%) in Oxygen group. No death and equipment defects were reported during study period. Conclusions: The trial demonstrated that hydrogen/oxygen therapy is superior to oxygen therapy in patient with AECOPD with acceptable safety and tolerability profile. Trial registration: Name of the registry: U.S National Library of Medicine Clinical Trials; Trial registration number: NCT04000451; Date of registration: June 27, 2019-Retrospectively registered; URL of trial registry record: https://www.clinicaltrials.gov/ct2/show/study/NCT04000451?term=04000451&draw=2&rank=1 . Keywords: Acute exacerbation; Chronic obstructive pulmonary disease; Hydrogen; Outcome; Oxygen.