General Research
Model: rat
Hydrogen regulates the M1/M2 polarization of alveolar macrophages in a rat model of chronic obstructive pulmonary disease
Simplified Version Available
How Hydrogen Helps Fight Chronic Obstructive Pulmonary Disease
A recent study found that hydrogen therapy may help reduce inflammation and improve lung function in people with Chronic Obstructive Pulmonary Disease (COPD). The study used a rat model to show that hydrogen regulates the M1/M2 polarization of alveolar macrophages, which can reduce the negative effects of cigarette smoke on the lungs. This offers hope for new treatments for COPD, a condition that makes it hard to breathe.
Read Simplified ArticleAbstract
Publish Year 2021 Country China Rank Positive Journal Experimental Lung Research Primary Topic Lung Secondary TopicChronic Obstructive Pulmonary Disease Model Rat Tertiary TopicCigarette Smoke Exposure Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: Compared with the control rats, there were a significant decline in lung function, a marked inflammatory infiltration and pulmonary parenchymal remodeling and the increases of IL-6, TNF-α and TGF-β1 levels in BALF and lung tissue, but a lower expression of IL-10 in COPD rats. The iNOS mRNA and protein expression, as well as its optical density (OD), were increased significantly in lung tissue, while those of Arg-1 decreased significantly. H2 treatment improved the lung function and the parenchymal inflammation, reversed the increased levels of IL-6, TNF-α and TGF-β1, and the lower IL-10. Meanwhile, H2 also down-regulated the expression of iNOS, but up-regulated expression of Arg-1 in lung tissue.
Results
Conclusion: H2 reduces inflammation in the lung of COPD, which may be related to its inhibition of M1 type polarization and activation of M2 type polarization of alveolar macrophage.