General Research
Model: rat
Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat model
Simplified Version Available
How Hydrogen Gas Can Protect Your Brain After Carbon Monoxide Poisoning
A study found that hydrogen gas can protect the brain from damage caused by carbon monoxide poisoning. The research, conducted on rats, showed that inhaling hydrogen gas reduced brain damage. This discovery could lead to new treatments for carbon monoxide poisoning.
Read Simplified ArticleAbstract
Publish Year 2019 Country China Rank Positive Journal Neurological Research Primary Topic Brain Secondary TopicEnvironmental Pollution Model Rat Tertiary TopicCarbon Monoxide Poisoning Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: Our results showed that CO poisoning significantly impaired neurological function which was improved over time, and HCH markedly attenuated neurological impairment following CO poisoning. In addition, CO poisoning resulted in increased levels of malondialdehyde, 3-nitrotyrosine and 8-hydroxy-2-deoxyguanosine and markedly reduced superoxide dismutase activity at 1 and 9 days, which were significantly inhibited by HCH at 9 days. Finally, CO poisoning increased the mRNA and protein levels of Nrf2 and downstream genes, and HCH further induced the anti-oxidative capability.
Results
Conclusion: These findings indicate the neuroprotective effects of HCH on DEACMP, which are related to the activation of Nrf2 signaling pathway.