General Research Model: rat

Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy

Simplified Version Available

How Hydrogen Gas May Help Protect Your Heart During a Heart Attack

Hydrogen gas may help reduce damage to the heart during a heart attack by reducing stress on heart cells. This could lead to new treatments for heart attack patients. More research is needed, but the findings are promising.

Read Simplified Article

Abstract

Publish Year 2017 Country China Rank Positive Journal Cellular Physiology and Biochemistry Primary Topic Heart Secondary TopicHeart Attack Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Gas pH N/A Application Inhalation Comparison Complement

Methods

Results: Both inhaling 2% hydrogen and ischemic postconditioning treatment reduced the ischemic size and serum troponin I level in rats with I/R injury, and inhaling hydrogen showed a more curative effect compared with ischemic postconditioning treatment. Meanwhile inhaling hydrogen showed a better protective effect in attenuating tissue reactive oxygen species. Malondialdehyde levels and immunoreactivities against 8-hydroxy-2'-deoxyguanosine and inhibiting cardiac endoplasmic reticulum stress and down-regulating autophagy as compared with ischemic postconditioning treatment.

Results

Conclusion: These results revealed a better protective effect of hydrogen on myocardial ischemic/reperfusion injury in rats by attenuating endoplasmic reticulum stress and down-regulating autophagy compared with ischemic postconditioning treatment.