General Research
Model: rat
Hydrogen Attenuates Myocardial Injury in Rats by Regulating Oxidative Stress and NLRP3 Inflammasome Mediated Pyroptosis
Simplified Version Available
How Hydrogen Gas Can Help Protect Your Heart
A new study shows that hydrogen gas can help protect the heart from damage caused by heart attacks. By reducing oxidative stress and inflammation, hydrogen gas may be a new way to keep your heart healthy. The results are promising, but more research is needed to fully understand the benefits of hydrogen gas for heart health.
Read Simplified ArticleAbstract
Publish Year 2021 Country China Rank Positive Journal International Journal of Molecular Sciences Primary Topic Heart Secondary TopicHeart Attack Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Gas pH N/A Application Inhalation Comparison Complement
Methods
Results: H2 inhalation ameliorated the cardiac dysfunction, infarct size and inflammatory cell infiltration caused by AMI. Meanwhile, H2 inhalation reduced the concentration of serum Troponin I (TnI), brain natriuretic peptide (BNP), reactive oxygen species (ROS), cardiac malondialdehyde (MDA), and 8-OHdG. In addition, H2 inhalation inhibited cardiac inflammation and pyroptosis relative proteins expression.
Results
Conclusion: H2 effectively promoted heart functions in AMI rats by regulating oxidative stress and pyroptosis.
Purpose
Methods: Sixty-four rats were randomly divided into three groups (Sham, AMI, and H2). The left anterior descending coronary artery (LAD) of rats in the AMI and H2 groups was ligated, while rats in the Sham group were threaded without ligation. In addition, 2% H2 was administered by inhalation for 24 h after ligation in the H2 group. Transthoracic echocardiography was performed after H2 inhalation, followed by collection of the serum and cardiac tissue of all rats.