General Research
Model: human
Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis
Simplified Version Available
How Alkaline Water Can Help Kidney Patients
A study from Taiwan found that using alkaline water in dialysis can improve T-cell damage in patients with end-stage renal disease. The study's findings could have implications for other diseases that affect the immune system. Alkaline water has antioxidant properties that can help protect the body from damage caused by free radicals.
Read Simplified ArticleAbstract
Publish Year 2010 Country Taiwan Rank Positive Journal Nephrology, Dialysis, and Transplantation Primary Topic Kidney Secondary TopicHaemodialysis Model Human Tertiary TopicImmune Dysfunction Vehicle Water (Electrolysis) pH Alkaline Application Injection Comparison Complement
Background
Methods: We evaluated apoptosis formation by annexin V, CD25-related surface markers, and cytokine ratio of Th1/Th2 in CD4(+) T lymphocytes and Tc1/Tc2 in CD8(+) T lymphocytes of 42 ESRD patients haemodialysed with ERW for 1 year.
Methods
Results: In comparison to 12 healthy individuals, the ESRD patients had more T-cell apoptosis and less CD3(+), CD4(+) and CD8(+) T cells and CD25/CD69/CD94/CD3(+) phenotypes at baseline. Lower intracellular IL-2 and IFN-gamma levels in the Th1/CD4(+) and Tc1/CD8(+) cells and higher intracellular IL-4, IL-6 and IL-10 levels in the Th2/CD4(+) and Tc2/CD8(+) cells were also noted in the ESRD patients. After a 1-year ERW treatment, the patients had a decrease in T-cell apoptosis and increases in CD3(+), CD4(+) and CD8(+) cell numbers and CD25/CD69/CD94/CD3(+) phenotypes in the T cells. The intracellular IL-2 and IFN-gamma levels in the Th1/Tc1 cells significantly (P < 0.05) increased and the intracellular IL-4, IL-6 and IL-10 levels in the Th2/Tc2 cells decreased. Furthermore, the Th1/Th2 and Tc1/Tc2 cytokine ratios were improved toward a normal status.
Results
Conclusion: One-year ERW treatment effectively ameliorated T-cell apoptosis, altered CD25-related surface markers and intracellular cytokine profile in the HD patients.