General Research
Model: mouse
Effects of oral intake of hydrogen water on liver fibrogenesis in mice
Simplified Version Available
Hydrogen Water: Can it Help Protect Your Liver from Damage?
A 2014 study found that mice who drank hydrogen water had less liver scarring. This suggests hydrogen water might help protect the liver from damage. The science behind it involves hydrogen's antioxidant properties, which can reduce oxidative stress and potentially prevent liver fibrosis.
Read Simplified ArticleAbstract
Publish Year 2014 Country Japan Rank Positive Journal Hepatology Research Primary Topic Liver Secondary TopicLiver Disease Model Mouse Tertiary TopicFibrosis Vehicle Water (Dissolved) pH Neutral Application Ingestion Comparison Complement
Methods
Results: Oral intake of hydrogen water significantly suppressed liver fibrogenesis in the carbon tetrachloride and thioacetamide models, but these effects were not seen in the bile duct ligation model. Treatment of isolated hepatocyte with 1 μg/mL antimycin A generated hydroxyl radicals. Culturing in the hydrogen-rich medium selectively suppressed the generation of hydroxyl radicals in hepatocytes and significantly suppressed hepatocyte death induced by antimycin A; however, it did not suppress hepatic stellate cell activation.
Results
Conclusion: We conclude that hydrogen water protects hepatocytes from injury by scavenging hydroxyl radicals and thereby suppresses liver fibrogenesis in mice.