General Research
Model: rat
Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial Ischemia-reperfusion Injury
Simplified Version Available
How Hydrogen-Rich Water Can Help Protect Your Heart During a Heart Attack
Drinking hydrogen-rich water may help protect your heart during a heart attack by reducing damage to heart tissue. A study on rats found that hydrogen-rich water activated a signaling pathway that promotes healing and protects cells from damage. While more research is needed, the findings are promising for humans too.
Read Simplified ArticleAbstract
Publish Year 2020 Country China Rank Positive Journal Current Molecular Medicine Primary Topic Heart Secondary TopicHeart Attack Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Water (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Results: Among the hydrogen-rich water group, the PI3K/AKT signaling pathway was significantly activated, and FoxO1, Bim, and Caspase-3 mRNA and protein levels were significantly decreased in ischemia-reperfusion subgroup compared with the preischemic and ischemic subgroups. In the ischemia-reperfusion hydrogen-rich water group, PI3K, AKT and p-AKT mRNA and protein expression levels were increased while the FoxO1, Bim and Caspase-3 expression levels were significantly decreased compared with those in the corresponding control group (P<0.05).
Results
Conclusion: Hydrogen-rich water can activate the PI3K/AKT signaling pathway, alleviate ischemia-reperfusion injury in isolated rat hearts, and inhibit cardiomyocyte apoptosis.