General Research
Model: mouse
Effect of hydrogen-saline on lung injury and heme oxygenase-1 expression in the lung tissue of acute paraquat-intoxicated mice
Simplified Version Available
How Hydrogen-Rich Saline Can Help Protect Lungs from Toxic Damage
A study on mice found that hydrogen-rich saline can help reduce lung damage caused by paraquat poisoning. The results suggest that this treatment could potentially be used to protect human lungs from toxic damage. With more research, hydrogen-rich saline could become a powerful tool in the fight against lung disease.
Read Simplified ArticleAbstract
Publish Year 2015 Country China Rank Positive Journal Chinese Journal of Industrial Hygiene and Occupational Diseases Primary Topic Lung Secondary TopicEnvironmental Pollution Model Mouse Tertiary TopicPesticide Toxicity (Paraquat) Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: mice came to shortness of breath, exhaustion and death after poisoned. PQ+hydrogen saline group was more alleviative than PQ group. The lung MDA of PQ group was markedly increased at 6 h and 24 h and SOD was decreased at 6 h, 24 h, 3 d, 7 d, 14 d than normal control group. In Comparison with PQ group, the lung MDA was decreased at 24 h and SOD was increased at 24 h and 3 d (P < 0.05). HO-1 expression trend and distribution in PQ+hydrogen saline group are similar with PQ group, but were significantly higher than that of PQ group and the control group each time point (P < 0.05).
Results
Conclusion: Oxidative stress plays important roles in lung injury caused by paraquat. Hydrogen-saline may increase expression of HO-1 and alleviate oxidative stress damage in lung.