General Research
Model: rat
Effect of electrolyzed reduced water on malondialdehyde levels and neutrophil cells in aggressive periodontitis
Simplified Version Available
How Alkaline Water Can Help Fight Gum Disease
A study found that alkaline water can help reduce inflammation and damage caused by aggressive periodontitis. Drinking alkaline water or using it as a mouthwash could be a simple and natural way to help prevent or treat gum disease. Consult with your dentist or healthcare provider before making any changes to your oral health routine.
Read Simplified ArticleAbstract
Publish Year 2018 Country Indonesia Rank Positive Journal Tropical Journal of Pharmaceutical Research Primary Topic Mouth Secondary TopicPeriodontitis Model Rat Tertiary TopicInflammation Vehicle Water (Electrolysis) pH Alkaline Application Irrigation Comparison Complement
Methods
Results: The number of neutrophils in the control group (30.04 ± 15.30) was higher than that of the treatment group (7.76 ± 2.52), while the MDA levels of the control and treatment groups were 4.58 ± 0.66 and 4.30 ± 0.81, respectively (p < 0.05).
Results
Conclusion: ERW demonstrates the ability to reduce neutrophil cells without altering MDA levels in Wistar rats suffering from aggressive periodontitis. This is an indication that ERW was an effective material to manage aggressive periodontitis. © 2018, Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.
Purpose
Methods: Wistar rats (Rattus norvegicus) were infected with A. actinomycetemcomitans before being divided into a control group and a treatment group. The control group was treated orally with distilled water (pH 7.0), while the treatment group was administered with ERW (pH 9.8, 20 ml/day) for three successive days. Gingival tissue taken post-treatment was examined to determine the number of neutrophils and MDA level. Hematoxylin eosin staining was performed to identify neutrophil cells while MDA levels were determined by colorimetric assay.