General Research
Model: pig
Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model
Simplified Version Available
How Hydrogen-Rich Saline Could Bring Relief to Allergy Sufferers
A 2017 study found that hydrogen-rich saline reduced inflammation in guinea pigs with allergic rhinitis, suggesting it could be a useful treatment for allergies. Hydrogen therapy has anti-inflammatory properties and is being explored for various health conditions. While more research is needed, the study provides promising evidence for the future of allergy treatment.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal Allergologia et Immunopathologia Primary Topic Nose Secondary TopicRhinitis Model Guinea Pig Tertiary TopicInflammation Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Methods: An AR guinea pig model was established by nasal ovalbumin sensitisation. Eighteen guinea pigs were divided into three groups, namely, saline control, AR-sensitised, and hydrogen-rich saline (HRS)-treated groups, with each group having six guinea pigs. The frequencies of sneezing and scratching were recorded. The IgE level and cytokine (IL-4 and IL-13) levels in the serum were measured. The expression levels of IL-4 and IL-13 mRNA and protein in the nasal mucosa were also determined by real-time reverse transcriptase-polymerase chain reaction and Western blot. We also observed the infiltration of cytokine (IL-4 and IL-13) in nasal mucosa by immunofluorescence.
Methods
Results: The frequencies of sneezing and scratching, as well as the levels of IgE, IL-4, and IL-13, in the serum were higher in the AR group than in the control group (p<0.01), whereas all these parameters were decreased significantly after HRS treatment (p<0.05). The expression levels of IL-4 and IL-13 mRNA and protein in the nasal mucosa were also lower in guinea pigs treated with HRS than those in the AR group (p<0.05). Conclusions: HRS could affect anti-inflammation in AR and decreased the expression of IL-4 and IL-13.