General Research
Model: rat
Beneficial Effects of Hydrogen-Rich Saline on Early Burn-Wound Progression in Rats
Simplified Version Available
Healing Burns with Hydrogen: How a Simple Solution Can Make a Big Difference
Researchers in China found that hydrogen-rich saline can significantly improve the healing process of burn wounds in rats. The solution reduces inflammation, promotes tissue repair, and helps prevent infection. This discovery has exciting implications for humans, offering a potential safe and effective way to promote healing and reduce complications.
Read Simplified ArticleAbstract
Publish Year 2015 Country China Rank Positive Journal PLoS One Primary Topic Skin Secondary TopicWound Healing Model Rat Tertiary TopicBurn Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: The burn-induced increase in malondialdehyde was markedly reduced with HS, while the activities of endogenous antioxidant enzymes were significantly increased. Moreover, HS treatment attenuated increases in apoptosis and autophagy postburn in wounds, according to the TUNEL staining results and the expression analysis of Bax, Bcl-2, caspase-3, Beclin-1 and Atg-5 proteins. Additionally, HS lowered the level of myeloperoxidase and expression of TNF-α, IL-1β, and IL-6 in the zone of stasis while augmenting IL-10. The elevated levels of Akt phosphorylation and NF-κB p65 expression post burn were also downregulated by HS management.
Results
Conclusion: Hydrogen can attenuate early wound progression following deep burn injury. The beneficial effect of hydrogen was mediated by attenuating oxidative stress, which inhibited apoptosis and inflammation, and the Akt/NF-κB signalling pathway may be involved in regulating the release of inflammatory cytokines.