General Research
Model: rat
Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water
Simplified Version Available
How Hydrogen Water May Help Protect Your Heart During a Heart Attack
A 2019 study found that hydrogen-rich water may help protect the heart during a heart attack by reducing damage caused by reperfusion injury. Hydrogen gas is a powerful antioxidant that can neutralize free radicals and support heart health. You can make hydrogen water at home using a water ionizer or hydrogen generator.
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Publish Year 2019 Country China Rank Positive Journal Current Molecular Medicine Primary Topic Heart Secondary TopicHeart Attack Model Rat Tertiary TopicIschemia-Reperfusion Injury Vehicle Water (Dissolved) pH Neutral Application Bath Comparison Complement
Background
Methods: In total, 20 male Wistar rats were evaluated for the effects of hydrogen-rich water on ischaemia-reperfusion in hearts. Left ventricular tissue was taken for screening and analysis of active protein factors by protein chip technology. The enrichment of the KEGG pathway was obtained by using the Gene Ontology (GO) enrichment principle. The expression of JAK2, STAT1, STAT3, p-STAT1, p-JAK2, p-STAT3 in rat myocardium was detected by Western blot analysis and immunohistochemistry. The apoptosis rates of the control and hydrogen-rich water groups were detected by TUNEL staining.
Methods
Results: The expression levels of 25 proteins, including five transduction pathways, were downregulated in the hydrogen-rich water group. The expression levels of p- JAK2/JAK2, p-STAT3/STAT3 were upregulated in the hydrogen-rich water group compared with the control group, and p-STAT1/STAT1 was downregulated in the hydrogen-rich water group compared with the control group. Furthermore, the apoptosis rate was significantly decreased in the hydrogen-rich water group, as well.
Results
Conclusion: Hydrogen-rich water may inhibit the apoptosis of cardiomyocytes after ischaemia-reperfusion by upregulating the expression of the JAK2-STAT3 signalling pathway, which reduces ischaemia-reperfusion injury.