General Research
Model: human
A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial
Simplified Version Available
Hydrogen Water: A Promising Breakthrough for Kidney Health
A clinical trial in Japan found that hydrogen water can improve kidney health by reducing oxidative stress. Hydrogen water can be made at home using a water ionizer or hydrogen generator. This breakthrough could be a game-changer for kidney health, and more research is being done to explore its benefits.
Read Simplified ArticleAbstract
Publish Year 2010 Country Japan Rank Positive Journal Nephrology, Dialysis, and Transplantation Primary Topic Kidney Secondary TopicHaemodialysis Model Human Tertiary TopicOxidative Stress Vehicle Water (Electrolysis) pH Alkaline Application Injection Comparison Complement
Background
Methods: Dialysis solution with H(2) (average of 48 ppb) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H(2) generated by a water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at three sessions a week.
Methods
Results: During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; P < 0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and myeloperoxidase (P < 0.05) were identified. Conclusions: Adding H(2) to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.