General Research
Model: mouse
Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice
Simplified Version Available
Hydrogen Therapy for Heart Health: A Promising Breakthrough for Diabetics
A 2015 study found that hydrogen therapy can help alleviate cardiac dysfunction in diabetic mice. The study suggests that drinking hydrogen-rich water or inhaling hydrogen gas could be a simple and effective way to support heart health. While more research is needed, the results are promising for humans with diabetes.
Read Simplified ArticleAbstract
Publish Year 2015 Country China Rank Positive Journal Cardiovascular Pathology Primary Topic Heart Secondary TopicDiabetes Model Mouse Tertiary TopicCardiomyopathy Vehicle Water (Dissolved) pH Neutral Application Ingestion Comparison Complement
Methods
Results: Although treatment of diabetic mice with hydrogen water did not significantly affect blood glucose level, it significantly attenuated cardiac hypertrophy and reduced expression of atrial natriuretic factor and β-myosin heavy chain; it alleviated cardiac fibrosis and reduced expression of collagen I and III, transforming growth factor beta, alpha-smooth muscle actin, and osteopontin; it reduced cardiac caspase-3 activity and ratio of bax/bcl-2. Importantly, hydrogen water treatment improved cardiac function in streptozotocin-diabetic mice. Furthermore, it was found that hydrogen water treatment abated oxidative stress, suppressed inflammation, and attenuated endoplasmic reticulum stress in the hearts of streptozotocin-diabetic mice. In addition, hydrogen water treatment suppressed activation of Jun NH2-terminal kinase and p38 mitogen activated protein kinase signaling and nuclear factor κB signaling in the hearts of streptozotocin-diabetic mice.
Results
Conclusion: Treatment with hydrogen molecule attenuated cardiac dysfunction in streptozotocin-induced diabetic mice, which was independent of glycemic control. Summary: Treatment with hydrogen molecule attenuated cardiac dysfunction in streptozotocin-induced type 1 diabetic mice. Molecular hydrogen could thus be envisaged as a nutritional countermeasure for diabetic cardiomyopathy.