General Research
Model: rat
The reason for the amelioration of N-methyl-N-nitrosoureainduced retinitis pigmentosa in rats by hydrogen-rich saline
Simplified Version Available
Hydrogen-Rich Saline: A Potential Treatment for Retinitis Pigmentosa
A study published in the International Journal of Ophthalmology found that hydrogen-rich saline improved retinitis pigmentosa in rats. This simple solution could potentially reduce vision loss and improve the quality of life for people with this condition. More research is needed, but the results are promising and offer new hope for those affected.
Read Simplified ArticleAbstract
Publish Year 2017 Country China Rank Positive Journal International Journal of Ophthalmology Primary Topic Eye Secondary TopicRetinal Injury Model Rat Tertiary TopicRetinitis Pigmentosa Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: HRS preserved the retinal function and mitigated the reduction of photoreceptor degeneration in MNU-treated retinas. The presence of microglia cells was somewhat more obvious in H group than that in M group at d1. HRS suppressed the further activation of microglia cells, with the number of microglia cells less than that of M group at d3. Results of qRT-PCR of Iba1 were consistent with those of immunofluorescence staining, with the mRNA expression of Iba1 in H group more intensive than that of M group at d1 (P<0.05), while less than that of M group at d3 (P<0.05). Furthermore, the Sirt1 mRNA and protein expression decreased after MNU administration, while HRS mitigated the MNU-induced downregulation of Sirt1.
Results
Conclusion: HRS can effectively keep microglia activation induced by MNU to an appropriate extent, while upregulate Sirt1 in MNU-induced RP.