General Research
Model: rat
Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury
Simplified Version Available
Healing Wounds Faster: How Oxygen and Hydrogen Work Together
A 2015 study in China found that hyperbaric oxygen preconditioning and hydrogen-rich saline work together to reduce wound damage and promote healing. This could lead to new treatments for people with wounds or surgery. The combination may help with conditions affecting blood flow, like diabetes.
Read Simplified ArticleAbstract
Publish Year 2015 Country China Rank Positive Journal Plastic and Aesthetic Research Primary Topic Skin Secondary TopicSurgery/Transplantation Model Rat Tertiary TopicPlastic Surgery Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement Oxygen
Methods
Results: Prior studies have shown the protective effects of HBO and HRS, both of which have been associated with an increase in flap survival. Compared to the IR group, the flaps in the HBO, HRS, and HBO + HRS groups showed better perfusion and a larger survival area with a low number of apoptotic cells, low caspase-3 activity and pASK1 expression, and a high Bcl-2/Bax ratio and Bcl-2 mRNA expression. Of these groups, the HBO + HRS group showed the best flap survival.
Results
Conclusion: Both HBO and HRS treatments increase the rate of flap survival, while the synergistic application of HBO and HRS showed a higher survival rate as compared to individual treatments of each. The potential regulation of apoptosis with the use of these two modalities may improve skin flap survival.