General Research
Model: pig
Saturated hydrogen saline protects against noise–induced hearing loss
Simplified Version Available
Can Hydrogen-Rich Saline Protect Your Hearing from Loud Noises?
A study found that saturated hydrogen saline may protect against noise-induced hearing loss. The solution, rich in hydrogen gas, has antioxidant properties that help reduce cell damage caused by loud noises. This could be especially useful for people who work in noisy environments or enjoy loud music.
Read Simplified ArticleAbstract
Publish Year 2011 Country China Rank Positive Journal Journal of Otology Primary Topic Ear Secondary TopicHearing Loss Model Guinea Pig Tertiary TopicNoise Pollution Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: Immediately after noise exposure, ABR thresholds in saturated hydrogen saline treated animals were lower than the non–treated animals (P < 0.05). Microscopy showed little SDH staining, cell swelling and irregular cell arrangement in the non–treated or normal saline treated animals. Whereas in the saturated hydrogen saline treated animals, there was deep SDH staining with significantly reduced cell loss and more regular cellular arrangement compared to the other two groups. The surviving cells counts was 45.17 ± 12.15 for non–treated animals, 44.50 ± 10.02 for normal saline treated animals and,116.50±2.38 for animals treated with saturated hydrogen saline. While the count was similar between non–treated and normal saline treated animals, it was significantly higher in saturated hydrogen saline treated animals (P < 0.05). Conclusions: Intraperitoneal injection of saturated hydrogen saline appears to protect the cochlea against noise–induced damage.