General Research
Model: mouse
Saturated hydrogen alleviates CCl 4 -induced acute kidney injury via JAK2/STAT3/p65 signaling
Simplified Version Available
Hydrogen Therapy: A Promising Solution for Kidney Injury
A recent study found that hydrogen therapy can help alleviate acute kidney injury by reducing inflammation. This promising new treatment could have applications for other health conditions, such as lung disease and chronic fatigue syndrome. Hydrogen therapy is a relatively safe and non-invasive treatment that shows potential for protecting the kidneys and other organs from damage.
Read Simplified ArticleAbstract
Publish Year 2020 Country China Rank Positive Journal Journal of International Medical Research Primary Topic Kidney Secondary TopicAcute Kidney Injury Model Mouse Tertiary TopicAcute Tubuluar Necrosis Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Methods
Results: Compared with untreated mice with CCl4-induced AKI, mice that were treated with saturated hydrogen exhibited improved renal function and reduced oxidative stress. Moreover, expression levels of p-JAK2, p-STAT3, and p-p65 were significantly reduced in mice treated with saturated hydrogen, compared with expression levels in untreated mice. Conclusions: Treatment with saturated hydrogen can reduce oxidative stress and inflammatory cytokine activation, potentially through inhibition of JAK2/STAT3/p65 signaling, thereby protecting against AKI.