General Research
Model: human
Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress
Simplified Version Available
Healing the Brain: How Hydrogen-Rich Saline Fights Traumatic Injuries
Scientists in China found that hydrogen-rich saline can help reduce oxidative stress in rats with brain injuries, which could lead to new treatments for people. The study shows promise for using hydrogen-rich saline to protect the brain and reduce inflammation. This could lead to better outcomes for people with brain injuries and a better understanding of how to keep our brains healthy.
Read Simplified ArticleAbstract
Publish Year 2012 Country China Rank Positive Journal Journal of Surgical Research Primary Topic Brain Secondary TopicTraumatic Brain Injury Model Rat Tertiary TopicOxidative Stress Vehicle Saline (Dissolved) pH Neutral Application Injection Comparison Complement
Background
Methods: TBI model was induced by controlled cortical impact injury. Different dosages of HS were intraperitoneally administered at 5 min after TBI operation. We then measured the brain edema, blood-brain barrier (BBB) breakdown, neurological dysfunction and injury volume in all animals. In addition, the oxidative products and antioxidant enzymes in brain tissues were detected.
Methods
Results: TBI-challenged rats exhibited significant brain injuries characterized by the increase of BBB permeability, brain edema, and lesion volume as well as neurological dysfunction, which were dose-dependently ameliorated by HS treatment. Moreover, we found that HS treatment increased the endogenous antioxidant enzymatic activities and decreased the oxidative product levels in brain tissues of TBI-challenged rats.
Results
Conclusion: Hydrogen-rich saline can exert a protective effect against TBI via reducing oxidative stress. Molecular hydrogen may be a more effective therapeutic strategy for TBI patients.